Brain injury after intracerebral hemorrhage: the role of thrombin and iron.
نویسندگان
چکیده
Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic targets. This article reviews the role of thrombin and iron in ICH-induced injury.
منابع مشابه
The relationship between the serum levels of ferritin and the radiological brain injury indices in patients with spontaneous intracerebral hemorrhage
Objective(s): Preclinical studies show that iron plays a key role in mediating neuronal injury. This study was performedin order to identify the relationship between the serum level of ferritin and severity of the brain injury which occur after an Intracerebral hemorrhage (ICH). Materials and Methods:This was a cross sectional descriptive – analytic study, which was conducted on those patients ...
متن کاملBrain Injury After Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic t...
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ورودعنوان ژورنال:
- Stroke
دوره 38 2 Suppl شماره
صفحات -
تاریخ انتشار 2007